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CS-W001157 4
Total: USD 88.00

2-Boc-amino-6-chloro-nicotinic acid

  • CAS No. 1224194-44-8

  • Cat. No. CS-0040620
  • Purity≥95%
  • MDL No.MFCD11847659

*For research and further manufacturing use only, not for direct human use.

2-Boc-amino-6-chloro-nicotinic acid|CS-0040620

Structure of 1224194-44-8

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General Information

  • CAS No. 1224194-44-8
  • Cat. No. CS-0040620
  • Purity ≥95%
  • MDL No. MFCD11847659
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₃ClN₂O₄
  • Molecular Weight None
  • Synonym(s) 2-(tert-butoxycarbonylamino)-6-chloro-pyridine-3-carboxylic acid
  • SMILES O=C(C1=CC=C(Cl)N=C1NC(OC(C)(C)C)=O)O

Description

2-Boc-amino-6-chloro-nicotinic acid features a sterically protected amine group flanked by a chlorinated pyridine core, enabling stable incorporation into peptide and heterocyclic syntheses. This bench-stable derivative facilitates efficient access to bioactive scaffolds under standard conditions.

Application

2-Boc-amino-6-chloro-nicotinic acid serves as a versatile building block for the synthesis of substituted nicotinamide derivatives and heterocyclic scaffolds. The Boc-protected amine enables orthogonal functional group manipulation, while the 6-chloro substituent facilitates palladium-catalyzed cross-coupling reactions. Its bench-stable nature and compatibility with standard purification methods make it well-suited for medicinal chemistry campaigns and API intermediate development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   88.52
  • LogP   2.7802
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   2

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