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Structure of 936-16-3
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This bench-stable heterocycle features a fused benzene ring and a sulfonated isothiazole core, delivering enhanced solubility and metabolic stability. The 1,1-dioxide functionality imparts strong electron-withdrawing character, enabling use in cross-coupling reactions and as a bioisostere in medicinal chemistry.
2,3-Dihydrobenzo[d]isothiazole 1,1-dioxide serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to sulfonamide-containing scaffolds. Its bench-stable structure exhibits favorable functional group tolerance and facilitates downstream derivatization via nucleophilic substitution or transition-metal-catalyzed coupling reactions. The molecule functions as a key intermediate in the synthesis of bioactive compounds, particularly those requiring rigid, electron-deficient aromatic systems with orthogonal reactivity.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: