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Structure of 1221171-88-5
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5-Trifluoromethoxy-pyridin-2-ylamine features a trifluoromethoxy group at the 5-position and an amino substituent at the 2-position of a pyridine ring, creating a strongly electron-deficient heteroaromatic scaffold. This configuration enables direct incorporation into pharmaceutical intermediates, particularly those requiring enhanced metabolic stability and controlled electronic properties in kinase inhibitor scaffolds.
5-Trifluoromethoxy-pyridin-2-ylamine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling reactions. Its trifluoromethoxy group enhances metabolic stability and modulates lipophilicity, while the primary amine facilitates further derivatization. The compound exhibits good bench stability and is compatible with common functional group transformations, making it well-suited for lead optimization and API development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: