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CS-W001157 4
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2-Methyloxazole-5-carboxylic acid

  • CAS No. 1216012-87-1

  • Cat. No. CS-W006682
  • Purity≥98%
  • MDL No.MFCD12403806

*For research and further manufacturing use only, not for direct human use.

2-Methyloxazole-5-carboxylic acid|CS-W006682

Structure of 1216012-87-1

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General Information

  • CAS No. 1216012-87-1
  • Cat. No. CS-W006682
  • Purity ≥98%
  • MDL No. MFCD12403806
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅NO₃
  • Molecular Weight 127.10
  • Synonym(s) 2-Methyl-oxazole-5-carboxylic acid
  • SMILES O=C(C1=CN=C(C)O1)O

Description

2-Methyloxazole-5-carboxylic acid features a fused heterocyclic core with a carboxylic acid group at the 5-position and a methyl substituent at the 2-position. This electron-deficient oxazole scaffold enables direct integration into bioactive molecules, offering enhanced metabolic stability and favorable solubility profiles in polar organic solvents.

Application

2-Methyloxazole-5-carboxylic acid serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to oxazole-containing scaffolds via standard coupling and functionalization protocols. Its carboxylic acid group facilitates amide bond formation and derivatization under mild conditions, while the methyl substituent enhances metabolic stability and modulates electronic properties. The compound exhibits good bench stability and compatibility with common protecting group strategies, making it well-suited for iterative synthesis campaigns targeting bioactive molecules.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   63.33
  • LogP   0.68122
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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