6-Bromo-1,3,3-trimethylindolin-2-one

Name: 6-Bromo-1,3,3-trimethylindolin-2-one
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1190861-69-8
Cat. No. CS-0068948
Purity≥98%
MDL No.MFCD28133542

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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6-Bromo-1,3,3-trimethylindolin-2-one|CS-0068948

Structure of 1190861-69-8

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General Information

CAS No. 1190861-69-8
Cat. No. CS-0068948
Purity ≥98%
MDL No. MFCD28133542
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₁₂BrNO
Molecular Weight 254.12
Synonym(s) 6-bromo-1,3,3-trimethylindol-2-one
SMILES O=C1N(C)C2=C(C=CC(Br)=C2)C1(C)C

Description

6-Bromo-1,3,3-trimethylindolin-2-one features a brominated indolinone scaffold with enhanced stability and solubility in organic media. The electron-deficient aryl bromide enables efficient cross-coupling reactions, while the sterically shielded 3,3-dimethyl substitution prevents undesired side reactions. This compound serves as a key building block for synthesizing bioactive heterocycles under standard coupling conditions.

Application

6-Bromo-1,3,3-trimethylindolin-2-one serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C6 position via palladium-catalyzed cross-coupling reactions. Its indolinone core provides inherent stability and compatibility with diverse reaction conditions, while the bromo group facilitates efficient derivatization. The trimethyl substitution enhances solubility and reduces aggregation during synthesis, supporting scalable access to complex heterocyclic scaffolds relevant to kinase inhibitor development.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H317
Precautionary Statements : P261-P264-P270-P272-P280-P302+P352-P330-P362+P364-P501

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Computational Chemistry Data

TPSA 20.31
LogP 2.7031
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Indolin compounds

Key Words

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6-Bromo-1,3,3-trimethylindolin-2-one

CAS No. 1190861-69-8

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