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CS-W001157 4
Total: USD 88.00

6-Bromo-5-fluoro-1H-indole

  • CAS No. 259860-08-7

  • Cat. No. CS-W008433
  • Purity≥96%
  • MDL No.MFCD10000894

*For research and further manufacturing use only, not for direct human use.

6-Bromo-5-fluoro-1H-indole|CS-W008433

Structure of 259860-08-7

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General Information

  • CAS No. 259860-08-7
  • Cat. No. CS-W008433
  • Purity ≥96%
  • MDL No. MFCD10000894
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅BrFN
  • Molecular Weight 214.03
  • Synonym(s) 6-Bromo-5-fluoroindole
  • SMILES FC1=CC2=C(NC=C2)C=C1Br

Description

6-Bromo-5-fluoro-1H-indole features a halogenated indole scaffold with strategic bromo and fluoro substituents at the 6- and 5-positions, respectively. This electron-deficient core enables direct functionalization in cross-coupling reactions, serving as a key building block for bioactive heterocycles. The molecule exhibits enhanced stability under standard handling conditions and integrates readily into complex molecular architectures via palladium-catalyzed transformations.

Application

6-Bromo-5-fluoro-1H-indole serves as a valuable building block for the synthesis of substituted indoles and heterocyclic scaffolds. Its dual halogenation pattern enables sequential cross-coupling reactions, facilitating efficient access to complex architectures. The molecule exhibits good bench stability and compatibility with standard Pd-catalyzed coupling protocols, supporting versatile functionalization in medicinal chemistry and materials science applications.

Synthesis

  • Route1
    • null|null
      1034894-73-9
    • ~91%
    • In-stock
      6-Bromo-5-fluoro-1H-indole|CS-W008433
      259860-08-7

    References

    • THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS Patent: WO2008/77138 A1, 2008 ; Location in patent: Page/Page column 77 ; WO 2008/077138 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   15.79
  • LogP   3.0695
  • H_Acceptors   0
  • H_Donors   1
  • Rotatable_Bonds   0

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