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CS-W001157 4
Total: USD 88.00

6-Bromo-4-fluoro-1H-indole

  • CAS No. 885520-59-2

  • Cat. No. CS-W019408
  • Purity≥96%
  • MDL No.MFCD07781550

*For research and further manufacturing use only, not for direct human use.

6-Bromo-4-fluoro-1H-indole|CS-W019408

Structure of 885520-59-2

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General Information

  • CAS No. 885520-59-2
  • Cat. No. CS-W019408
  • Purity ≥96%
  • MDL No. MFCD07781550
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅BrFN
  • Molecular Weight 214.04
  • Synonym(s) 6-BROMO-4-FLUORO INDOLE
  • SMILES FC1=CC(Br)=CC2=C1C=CN2

Description

6-Bromo-4-fluoro-1H-indole features a halogenated indole core with strategic bromo and fluoro substituents at the 6- and 4-positions, respectively. This electron-deficient scaffold enables direct functionalization in cross-coupling reactions, serving as a key building block for bioactive heterocycles and pharmaceutical intermediates.

Application

6-Bromo-4-fluoro-1H-indole serves as a valuable building block for the synthesis of biologically active heterocycles and pharmaceutical intermediates. Its ortho-halogenated indole core enables efficient palladium-catalyzed cross-coupling reactions, while the fluorine substituent enhances metabolic stability and modulates electronic properties. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for scalable medicinal chemistry campaigns and API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   15.79
  • LogP   3.0695
  • H_Acceptors   0
  • H_Donors   1
  • Rotatable_Bonds   0

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