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CS-W001157 4
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6-Bromo-5-fluoro-1H-indazole

  • CAS No. 1286734-85-7

  • Cat. No. CS-W022464
  • Purity≥95%
  • MDL No.MFCD18089816

*For research and further manufacturing use only, not for direct human use.

6-Bromo-5-fluoro-1H-indazole|CS-W022464

Structure of 1286734-85-7

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General Information

  • CAS No. 1286734-85-7
  • Cat. No. CS-W022464
  • Purity ≥95%
  • MDL No. MFCD18089816
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄BrFN₂
  • Molecular Weight 215.02
  • Synonym(s) 6-Bromo-5-fluoro indazole
  • SMILES FC1=C(Br)C=C2NN=CC2=C1

Description

6-Bromo-5-fluoro-1H-indazole is a halogenated indazole scaffold featuring complementary bromine and fluorine substituents at the 6- and 5-positions, respectively. This electron-deficient heterocycle serves as a key building block in medicinal chemistry, enabling direct coupling reactions via palladium-catalyzed cross-coupling. The strategic placement of halogens supports efficient diversification in target-oriented synthesis.

Application

6-Bromo-5-fluoro-1H-indazole serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The bromo group facilitates Suzuki, Stille, and Negishi couplings, while the fluorine enhances metabolic stability and modulates electronic properties. Its bench-stable crystalline form simplifies handling and purification, making it well-suited for iterative synthesis of complex heterocyclic scaffolds and API intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   28.68
  • LogP   2.4645
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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