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CS-W001157 4
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6-Bromo-2,3-dimethyl-2H-indazole

  • CAS No. 1142189-49-8

  • Cat. No. CS-0036963
  • Molecule weight225.09
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Bromo-2,3-dimethyl-2H-indazole|CS-0036963

Structure of 1142189-49-8

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General Information

  • CAS No. 1142189-49-8
  • Cat. No. CS-0036963
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉BrN₂
  • Molecular Weight 225.09
  • Synonym(s) 6-Bromo-2,3-dimethyl-indazole
  • SMILES CC1=C2C=CC(=CC2=NN1C)Br

Description

6-Bromo-2,3-dimethyl-2H-indazole features a sterically hindered indazole core with bromine and methyl groups at strategic positions, enabling direct functionalization in cross-coupling reactions. This bench-stable heterocycle integrates readily into complex scaffolds for medicinal chemistry and materials science applications.

Application

6-Bromo-2,3-dimethyl-2H-indazole serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its well-defined bromine handle. The molecule exhibits good bench stability and facilitates the construction of substituted indazole scaffolds through standard coupling protocols. Its methyl groups enhance lipophilicity and provide steric control in downstream functionalization, making it suitable for API development and target-oriented synthesis.

Synthesis

  • Route1

    References

    • Rhizen Pharmaceuticals SA; Incozen Therapeutics Pvt. Ltd. Patent: US2011/118257 A1, 2011 ; Location in patent: Page/Page column 100 ;
  • Route2

    References

    • Rhizen Pharmaceuticals SA; Incozen Therapeutics Pvt. Ltd. Patent: US2011/118257 A1, 2011 ;
  • Route3

    References

    • Rhizen Pharmaceuticals SA; Incozen Therapeutics Pvt. Ltd. Patent: US2011/118257 A1, 2011 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   17.82
  • LogP   2.64422
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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