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5-hydroxy-2-trifluoromethylpyridine

  • CAS No. 216766-12-0

  • Cat. No. CS-W008936
  • Molecule weight163.10
  • Purity≥97%
  • MDL No.MFCD06801325

*For research and further manufacturing use only, not for direct human use.

5-hydroxy-2-trifluoromethylpyridine|CS-W008936

Structure of 216766-12-0

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General Information

  • CAS No. 216766-12-0
  • Cat. No. CS-W008936
  • Purity ≥97%
  • MDL No. MFCD06801325
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄F₃NO
  • Molecular Weight 163.10
  • Synonym(s) 6-(Trifluoromethyl)pyridin-3-ol
  • SMILES FC(C1=NC=C(O)C=C1)(F)F

Description

5-Hydroxy-2-trifluoromethylpyridine features a trifluoromethyl group at the pyridine ring's 2-position and a hydroxyl substituent at the 5-position, creating a uniquely electron-deficient heterocyclic scaffold. This configuration enhances its utility in coupling reactions and as a building block for bioactive molecules. The molecule exhibits improved solubility and stability compared to non-fluorinated analogs.

Application

5-Hydroxy-2-trifluoromethylpyridine serves as a versatile building block for the synthesis of functionalized heterocycles and pharmaceutical intermediates. The hydroxyl group enables direct derivatization via etherification, esterification, or transition-metal-catalyzed coupling, while the trifluoromethyl moiety imparts enhanced metabolic stability and lipophilicity. Its bench-stable nature and compatibility with standard protecting group strategies facilitate efficient multistep synthesis in medicinal chemistry workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   1.806
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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