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CS-W001157 4
Total: USD 88.00

1-Phenylpiperidin-4-ol

  • CAS No. 117896-69-2

  • Cat. No. CS-0069832
  • Purity≥97%
  • MDL No.MFCD02093533

*For research and further manufacturing use only, not for direct human use.

1-Phenylpiperidin-4-ol|CS-0069832

Structure of 117896-69-2

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General Information

  • CAS No. 117896-69-2
  • Cat. No. CS-0069832
  • Purity ≥97%
  • MDL No. MFCD02093533
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₅NO
  • Molecular Weight 177.24
  • Synonym(s) 1-Phenyl-4-Piperidinol
  • SMILES OC1CCN(C2=CC=CC=C2)CC1

Description

1-Phenylpiperidin-4-ol features a rigid piperidine scaffold bearing a phenyl group and a hydroxyl moiety at the 4-position, enabling strong hydrogen-bonding interactions. This structural motif imparts enhanced solubility and metabolic stability, making it a valuable scaffold in medicinal chemistry for CNS-targeted drug discovery.

Application

1-Phenylpiperidin-4-ol serves as a versatile scaffold in medicinal chemistry, enabling the construction of bioactive molecules through standard functionalization at the hydroxyl and piperidine nitrogen positions. Its bench-stable nature and compatibility with common coupling and reduction protocols facilitate efficient synthesis of opioid receptor ligands and CNS-targeted compounds.

Synthesis

  • Route1
    • null|null
      117896-64-7
    • ~48%
    • In-stock
      1-Phenylpiperidin-4-ol|CS-0069832
      117896-69-2

    References

    • Murahashi, Shun-Ichi; Naota, Takeshi; Yonemura, Koichi Journal of the American Chemical Society, 1988 , vol. 110, # 24 p. 8256 - 8258
  • Route2
    • null|null
      13424-22-1
    • ~%
    • In-stock
      1-Phenylpiperidin-4-ol|CS-0069832
      117896-69-2

    References

    • Murahashi, Shun-Ichi; Naota, Takeshi; Yonemura, Koichi Journal of the American Chemical Society, 1988 , vol. 110, # 24 p. 8256 - 8258
  • Route3
    • null|null
      19125-34-9
    • ~%
    • In-stock
      1-Phenylpiperidin-4-ol|CS-0069832
      117896-69-2

    References

    • Girard, Nicolas; Hurvois, Jean-Pierre Tetrahedron Letters, 2007 , vol. 48, # 23 p. 4097 - 4099

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   23.47
  • LogP   1.6477
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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