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CS-W001157 4
Total: USD 88.00

1-(4-Aminophenyl)piperidin-4-ol

  • CAS No. 142752-12-3

  • Cat. No. CS-0095211
  • Purity≥97%
  • MDL No.MFCD09738905

*For research and further manufacturing use only, not for direct human use.

1-(4-Aminophenyl)piperidin-4-ol|CS-0095211

Structure of 142752-12-3

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General Information

  • CAS No. 142752-12-3
  • Cat. No. CS-0095211
  • Purity ≥97%
  • MDL No. MFCD09738905
  • Storage RT, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₆N₂O
  • Molecular Weight 192.26
  • Synonym(s) 4-Piperidinol, 1-(4-aminophenyl)-
  • SMILES OC1CCN(C2=CC=C(N)C=C2)CC1

Description

1-(4-Aminophenyl)piperidin-4-ol features a piperidin-4-ol core linked to an aniline moiety, delivering a rigid, electron-rich scaffold with enhanced solubility and metabolic stability. This structural motif integrates seamlessly into kinase inhibitor frameworks and bioactive molecule design, offering favorable pharmacokinetic properties and efficient derivatization under standard conditions.

Application

1-(4-Aminophenyl)piperidin-4-ol serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through standard coupling and functionalization protocols. Its amine and hydroxyl functionalities provide orthogonal handles for derivatization, while the piperidine core offers favorable pharmacokinetic properties. Bench-stable and readily purified, it functions effectively in multi-step syntheses targeting CNS-active compounds and kinase inhibitors.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   49.49
  • LogP   1.2299
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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