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CS-W001157 4
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4-(4-Hydroxypiperidin-1-yl)benzaldehyde

  • CAS No. 79421-44-6

  • Cat. No. CS-0157482
  • Molecule weight205.25
  • Purity≥98%
  • MDL No.MFCD05864666

*For research and further manufacturing use only, not for direct human use.

4-(4-Hydroxypiperidin-1-yl)benzaldehyde|CS-0157482

Structure of 79421-44-6

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General Information

  • CAS No. 79421-44-6
  • Cat. No. CS-0157482
  • Purity ≥98%
  • MDL No. MFCD05864666
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₅NO₂
  • Molecular Weight 205.25
  • Synonym(s) 4-(4-Hydroxy-1-piperidinyl)benzaldehyde
  • SMILES C1=C(C=CC(=C1)N2CCC(CC2)O)C=O

Description

4-(4-Hydroxypiperidin-1-yl)benzaldehyde features a hydroxypiperidine moiety linked to an aromatic aldehyde, enabling direct conjugation or derivatization in medicinal chemistry. The pendant hydroxyl group enhances solubility and facilitates further functionalization. This scaffold integrates readily into bioactive molecules requiring polar, hydrogen-bonding capabilities.

Application

4-(4-Hydroxypiperidin-1-yl)benzaldehyde serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and targeted pharmaceutical scaffolds. The aldehyde functionality facilitates efficient imine formation and reductive amination, while the hydroxypiperidine moiety offers hydrogen-bonding capacity and metabolic stability. Bench-stable and compatible with standard coupling protocols, it functions effectively in multi-step syntheses requiring orthogonal functional group handling.

Synthesis

  • Route1
    • null|null
      5382-16-1
    • p-Fluorobenzenecarboxaldehyde Atorvastatin calcium|CS-0214005
      459-57-4
    • ~83%
    • In-stock
      4-(4-Hydroxypiperidin-1-yl)benzaldehyde|CS-0157482
      79421-44-6

    References

    • Taylor, Edward C.; Skotnicki, Jerauld S. Synthesis, 1981 , # 8 p. 606 - 608

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   40.54
  • LogP   1.4602
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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