Lot numbers can be found on the outside label of a product:
AC-Asp(OtBU)-OH
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CAS No. 117833-18-8
- Cat. No. CS-0061065
- Purity≥97%
- MDL No.MFCD00236746
*For research and further manufacturing use only, not for direct human use.
Structure of 117833-18-8
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General Information
- CAS No. 117833-18-8
- Cat. No. CS-0061065
- Purity ≥97%
- MDL No. MFCD00236746
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₀H₁₇NO₅
- Molecular Weight 231.25
- Synonym(s) None
- SMILES CC(N[C@H](C(O)=O)CC(OC(C)(C)C)=O)=O
Description
AC-Asp(OtBu)-OH is a protected aspartic acid derivative featuring a tert-butyl ester group, enabling stable incorporation into peptide synthesis workflows. This residue delivers enhanced solubility and compatibility in automated and manual coupling protocols, particularly valuable in the construction of complex bioactive sequences.
Application
AC-Asp(OtBu)-OH serves as a key building block in peptide synthesis, enabling efficient incorporation of protected aspartic acid residues. The OtBu group provides excellent stability and orthogonal deprotection compatibility, while the AC (acetyl) protection ensures controlled reactivity during coupling steps. This dipeptide precursor facilitates straightforward purification and is well-suited for solid-phase and solution-phase workflows in the construction of bioactive peptides and complex scaffolds.
Synthesis
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Route1
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108-24-7 -
In-stock
3057-74-7 - ~94%
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In-stock
117833-18-8
References
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Goode, David R.; Sharma, Anil K.; Hergenrother, Paul J. Organic Letters, 2005 , vol. 7, # 16 p. 3529 - 3532
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Route2
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In-stock
71989-14-5 -
108-24-7
- ~%
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In-stock
117833-18-8
References
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WO2014/56923 A1, ; Page/Page column 146; 147 ;
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References
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Piotrovskii, L. B.; Dumpis, M. A.; Poznyakova, L. N.; Aleksandrova, L. N.; Sepetov, N. F. Journal of Organic Chemistry USSR (English Translation), 1988 , vol. 24, p. 96 - 100 Zhurnal Organicheskoi Khimii, 1988 , vol. 24, # 1 p. 111 - 116
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 92.7
- LogP 0.3075
- H_Acceptors 4
- H_Donors 2
- Rotatable_Bonds 4
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Key Words
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