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CS-W001157 4
Total: USD 88.00

Ac-Glu(OtBu)-OH

  • CAS No. 84192-88-1

  • Cat. No. CS-0154013
  • Molecule weight245.27
  • Purity≥98%
  • MDL No.MFCD00236754

*For research and further manufacturing use only, not for direct human use.

Ac-Glu(OtBu)-OH|CS-0154013

Structure of 84192-88-1

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General Information

  • CAS No. 84192-88-1
  • Cat. No. CS-0154013
  • Purity ≥98%
  • MDL No. MFCD00236754
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₉NO₅
  • Molecular Weight 245.27
  • Synonym(s) (2S)-2-(acetylamino)-5-tert-butoxy-5-oxopentanoic acid (non-preferred name)
  • SMILES CC(N[C@H](C(O)=O)CCC(OC(C)(C)C)=O)=O

Description

Ac-Glu(OtBu)-OH is a protected glutamic acid derivative featuring a tert-butyl ester on the side-chain carboxylate and acetyl group at the N-terminus. This configuration enables stable incorporation into peptide chains during solid-phase synthesis, offering enhanced solubility and resistance to racemization under standard coupling conditions.

Application

Ac-Glu(OtBu)-OH serves as a key building block in peptide synthesis, offering a protected glutamic acid residue with orthogonal functionality. The acetyl group at the N-terminus ensures stability and prevents undesired side reactions, while the tert-butyl ester selectively protects the side-chain carboxylate. This configuration facilitates efficient coupling in solid-phase and solution-phase peptide assembly, enabling reliable access to complex sequences and biologically relevant scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   92.7
  • LogP   0.6976
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   5

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