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1-(Aminomethyl)cyclopropanecarbonitrile hydrochloride

  • CAS No. 1205544-78-0

  • Cat. No. CS-0036989
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(Aminomethyl)cyclopropanecarbonitrile hydrochloride|CS-0036989

Structure of 1205544-78-0

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General Information

  • CAS No. 1205544-78-0
  • Cat. No. CS-0036989
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₉ClN₂
  • Molecular Weight 132.59
  • Synonym(s) 1-aminomethyl-cyclopropanecarbonitrile hydrochloride
  • SMILES C1CC1(CN)C#N.Cl

Description

This cyclopropane-based nitrile features a tethered amine functionality, delivering enhanced solubility and reactivity in synthetic workflows. The hydrochloride salt form ensures stability and ease of handling, enabling efficient incorporation into peptide conjugates and bioactive molecule scaffolds under standard conditions.

Application

1-(Aminomethyl)cyclopropanecarbonitrile hydrochloride serves as a versatile building block for medicinal chemistry, enabling efficient access to cyclopropyl-containing scaffolds. Its bifunctional nature—combining a primary amine and nitrile group—facilitates diverse transformations, including amidation, reduction, and cyclization reactions. The hydrochloride salt enhances solubility and stability, supporting reliable handling in aqueous and polar organic media. This compound functions effectively in standard coupling protocols and is compatible with common protecting group strategies, making it valuable for the synthesis of bioactive molecules and API intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   49.81
  • LogP   0.67068
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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