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1-Bromo-2-methylpropan-2-ol

  • CAS No. 38254-49-8

  • Cat. No. CS-0139635
  • Purity≥97%
  • MDL No.MFCD20621218

*For research and further manufacturing use only, not for direct human use.

1-Bromo-2-methylpropan-2-ol|CS-0139635

Structure of 38254-49-8

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General Information

  • CAS No. 38254-49-8
  • Cat. No. CS-0139635
  • Purity ≥97%
  • MDL No. MFCD20621218
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₉BrO
  • Molecular Weight 153.02
  • Synonym(s) BroMo-tert-butyl Alcohol
  • SMILES CC(O)(C)CBr

Description

1-Bromo-2-methylpropan-2-ol features a tertiary alcohol scaffold bearing a bromine atom at the adjacent carbon, enabling efficient SN1 substitution under mild conditions. This bench-stable reagent integrates readily into synthetic sequences requiring rapid alkyl halide formation, particularly in the construction of quaternary centers and functionalized alkylating agents.

Application

1-Bromo-2-methylpropan-2-ol serves as a stable, bench-ready tertiary alkyl bromide that facilitates SN1-type reactions with high regioselectivity. Its steric hindrance enhances functional group tolerance, enabling efficient transformations in nucleophilic substitution workflows. The compound functions reliably in the synthesis of quaternary carbon centers and serves as a key building block for heterocyclic scaffolds and medicinal chemistry intermediates.

Synthesis

  • Route1
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    • ~%
    • In-stock
      1-Bromo-2-methylpropan-2-ol|CS-0139635
      38254-49-8

    References

    • Traynham; Pascual Tetrahedron, 1959 ,  vol. 7, p. 165,167, 169            

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   1.1522
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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