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CS-W001157 4
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4-Chloro-6-(trifluoromethyl)pyridin-2-amine

  • CAS No. 117519-06-9

  • Cat. No. CS-0441700
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Chloro-6-(trifluoromethyl)pyridin-2-amine|CS-0441700

Structure of 117519-06-9

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General Information

  • CAS No. 117519-06-9
  • Cat. No. CS-0441700
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄ClF₃N₂
  • Molecular Weight 196.56
  • Synonym(s) 4-Chloro-6-trifluoromethyl-pyridin-2-ylamine
  • SMILES C1=C(C=C(N)N=C1C(F)(F)F)Cl

Description

4-Chloro-6-(trifluoromethyl)pyridin-2-amine features a trifluoromethyl group that enhances electron deficiency and metabolic stability, while the chloro substituent enables direct functionalization. This pyridine scaffold integrates readily into pharmaceutical intermediates, offering robust reactivity under standard coupling conditions.

Application

4-Chloro-6-(trifluoromethyl)pyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds via palladium-catalyzed cross-coupling reactions. The chloro group facilitates reliable C–C and C–N bond formation under standard conditions, while the trifluoromethyl moiety imparts enhanced metabolic stability and lipophilicity. Its bench-stable nature and compatibility with diverse functional groups make it ideal for parallel synthesis campaigns and API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   2.336
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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