3-Chloro-6-(trifluoromethyl)pyridin-2-amine

Name: 3-Chloro-6-(trifluoromethyl)pyridin-2-amine
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CAS No. 886762-09-0
Cat. No. CS-0156787
Molecule weight196.56
Purity≥98%
MDL No.MFCD04037237

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3-Chloro-6-(trifluoromethyl)pyridin-2-amine|CS-0156787

Structure of 886762-09-0

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General Information

CAS No. 886762-09-0
Cat. No. CS-0156787
Purity ≥98%
MDL No. MFCD04037237
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₄ClF₃N₂
Molecular Weight 196.56
Synonym(s) 3-Chloro-6-trifluoromethyl-pyridin-2-ylamine
SMILES C1=CC(=NC(=C1Cl)N)C(F)(F)F

Description

3-Chloro-6-(trifluoromethyl)pyridin-2-amine delivers a potent electron-deficient pyridine scaffold with enhanced stability and solubility under standard conditions. This trifluoromethyl-substituted heterocycle integrates readily into medicinal chemistry campaigns, enabling efficient coupling reactions via its primary amine functionality.

Application

3-Chloro-6-(trifluoromethyl)pyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its reactive chloropyridine moiety. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the pyridin-2-amine functionality provides a handle for further derivatization via amide coupling or metal coordination. Its bench-stable nature and compatibility with diverse reaction conditions make it suitable for scalable synthesis of bioactive heterocycles.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P233-P260-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P340-P362-P403-P405-P501

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Computational Chemistry Data

TPSA 38.91
LogP 2.336
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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3-Chloro-6-(trifluoromethyl)pyridin-2-amine

CAS No. 886762-09-0

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