Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

3-Chloroisoquinoline

  • CAS No. 19493-45-9

  • Cat. No. CS-D0870
  • Purity≥96%
  • MDL No.MFCD05982009

*For research and further manufacturing use only, not for direct human use.

3-Chloroisoquinoline|CS-D0870

Structure of 19493-45-9

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 19493-45-9
  • Cat. No. CS-D0870
  • Purity ≥96%
  • MDL No. MFCD05982009
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₆ClN
  • Molecular Weight 163.60
  • Synonym(s) 3-chloroisoquinline
  • SMILES ClC1=CC2=CC=CC=C2C=N1

Description

3-Chloroisoquinoline serves as a pivotal building block in medicinal chemistry, offering a rigid, electron-deficient heterocyclic scaffold. This chlorinated isoquinoline integrates readily into diverse synthetic pathways, enabling efficient access to bioactive compounds through cross-coupling and nucleophilic substitution reactions. Its bench-stable nature supports reliable handling under standard conditions.

Application

3-Chloroisoquinoline serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C3 position via palladium-catalyzed cross-coupling reactions. Its moderate electrophilicity and bench stability facilitate incorporation into diverse heterocyclic scaffolds, particularly in the synthesis of kinase inhibitors and CNS-targeted compounds. The chlorine atom provides a reliable handle for further derivatization under standard conditions.

Synthesis

  • Route1

    References

    • ABBOTT LABORATORIES; GOMTSYAN, Arthur R.; VOIGHT, Eric A.; BAYBURT, Erol K.; CHEN, Jun; DAANEN, Jerome F.; DIDOMENICO, Stanley, Jr.; KORT, Michael E.; KYM, Philip R.; MCDONALD, Heath A.; PERNER, Richard J.; SCHMIDT, Robert G. Patent: WO2010/45402 A1, 2010 ; Location in patent: Page/Page column 87 ; WO 2010/045402 A1
  • Route2

    References

    • CANCER RESEARCH TECHNOLOGY LIMITED Patent: WO2009/103966 A1, 2009 ; Location in patent: Page/Page column 93-94 ; WO 2009/103966 A1
  • Route3
    • In-stock
      1,3-Dichloroisoquinoline|CS-W002162
      7742-73-6
    • null|null
      7440-31-5
    • ~%
    • In-stock
      3-Chloroisoquinoline|CS-D0870
      19493-45-9

    References

    • US2004/157849 A1, ; US 20040157849 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.8882
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 3-Chloroisoquinoline sigma3-Chloroisoquinoline manufacturer3-Chloroisoquinoline price3-Chloroisoquinoline structure3-Chloroisoquinoline SDSbuy 3-Chloroisoquinoline3-Chloroisoquinoline supplier3-Chloroisoquinoline uses3-Chloroisoquinoline molecular weightprice of 3-Chloroisoquinoline3-Chloroisoquinoline chemical name formula of 3-Chloroisoquinoline
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label