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CS-W001157 4
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5-(Difluoromethoxy)picolinic acid

  • CAS No. 1174323-34-2

  • Cat. No. CS-0086120
  • Purity≥98%
  • MDL No.MFCD18261162

*For research and further manufacturing use only, not for direct human use.

5-(Difluoromethoxy)picolinic acid|CS-0086120

Structure of 1174323-34-2

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General Information

  • CAS No. 1174323-34-2
  • Cat. No. CS-0086120
  • Purity ≥98%
  • MDL No. MFCD18261162
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅F₂NO₃
  • Molecular Weight 189.12
  • Synonym(s) 5-(difluoromethoxy)pyridine-2-carboxylic acid
  • SMILES O=C(C1=NC=C(OC(F)F)C=C1)O

Description

5-(Difluoromethoxy)picolinic acid is a fluorinated heterocyclic carboxylic acid featuring a difluoromethoxy group at the 5-position of the pyridine ring. This electron-deficient scaffold enhances metabolic stability and modulates lipophilicity, enabling direct incorporation into bioactive molecules. The carboxylic acid moiety facilitates coupling reactions for peptide conjugation or macrocyclization, offering a robust handle for medicinal chemistry campaigns targeting CNS and oncology applications.

Application

5-(Difluoromethoxy)picolinic acid serves as a versatile building block for bioactive heterocycles and pharmaceutical intermediates, offering enhanced metabolic stability through its difluoromethoxy group. The carboxylic acid functionality enables direct coupling reactions, while the picolinic core provides a rigid, planar scaffold compatible with transition-metal-catalyzed transformations. Bench-stable and amenable to standard purification methods, it facilitates efficient synthesis of targeted drug candidates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   59.42
  • LogP   1.3812
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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