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CS-W001157 4
Total: USD 88.00

5-(Trifluoromethoxy)picolinic acid

  • CAS No. 102771-66-4

  • Cat. No. CS-0080450
  • Purity≥95%
  • MDL No.MFCD10697540

*For research and further manufacturing use only, not for direct human use.

5-(Trifluoromethoxy)picolinic acid|CS-0080450

Structure of 102771-66-4

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General Information

  • CAS No. 102771-66-4
  • Cat. No. CS-0080450
  • Purity ≥95%
  • MDL No. MFCD10697540
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄F₃NO₃
  • Molecular Weight 207.11
  • Synonym(s) 5-(Trifluoromethoxy)pyridine-2-carboxylic acid
  • SMILES FC(F)(F)OC1=CC=C(C(O)=O)N=C1

Description

5-(Trifluoromethoxy)picolinic acid features a trifluoromethoxy group at the pyridine ring's 5-position, delivering enhanced electron-withdrawing character and metabolic stability. This configuration improves solubility in polar solvents and facilitates direct coupling in peptide synthesis and medicinal chemistry applications.

Application

5-(Trifluoromethoxy)picolinic acid serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its trifluoromethoxy group imparts enhanced metabolic stability and lipophilicity, while the pyridine carboxylic acid core enables facile derivatization via amide formation, esterification, or metal-catalyzed coupling reactions. The compound exhibits excellent bench stability and is compatible with standard purification methods, facilitating integration into diverse synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H317
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   59.42
  • LogP   1.6784
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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