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Structure of 1174323-34-2
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5-(Difluoromethoxy)picolinic acid is a fluorinated heterocyclic carboxylic acid featuring a difluoromethoxy group at the 5-position of the pyridine ring. This electron-deficient scaffold enhances metabolic stability and modulates lipophilicity, enabling direct incorporation into bioactive molecules. The carboxylic acid moiety facilitates coupling reactions for peptide conjugation or macrocyclization, offering a robust handle for medicinal chemistry campaigns targeting CNS and oncology applications.
5-(Difluoromethoxy)picolinic acid serves as a versatile building block for bioactive heterocycles and pharmaceutical intermediates, offering enhanced metabolic stability through its difluoromethoxy group. The carboxylic acid functionality enables direct coupling reactions, while the picolinic core provides a rigid, planar scaffold compatible with transition-metal-catalyzed transformations. Bench-stable and amenable to standard purification methods, it facilitates efficient synthesis of targeted drug candidates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: