2-Chloro-4-iodophenol

Name: 2-Chloro-4-iodophenol
Brand: ChemScene
Availability: InStock
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CAS No. 116130-33-7
Cat. No. CS-W006410
Purity≥95%
MDL No.MFCD11110536

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 116130-33-7

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Description

2-Chloro-4-iodophenol features a phenolic hydroxyl group flanked by chlorine and iodine substituents, enabling selective coupling reactions in medicinal chemistry. The electron-withdrawing halogens enhance reactivity in palladium-catalyzed cross-couplings while maintaining stability under standard conditions. This scaffold serves as a key building block for bioactive molecule synthesis.

Application

2-Chloro-4-iodophenol serves as a valuable building block in the synthesis of functionalized aromatic scaffolds, enabling direct coupling reactions via its orthogonal halogenation pattern. The chloro group facilitates palladium-catalyzed cross-coupling, while the iodo substituent offers high reactivity in Suzuki, Stille, and Negishi transformations. Its bench-stable crystalline form simplifies handling and purification, making it well-suited for iterative medicinal chemistry campaigns and API intermediate development.

General Information

CAS No. 116130-33-7
Cat. No. CS-W006410
Purity ≥95%
MDL No. MFCD11110536
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₄ClIO
Molecular Weight 254.45
Synonym(s) 4-iodo-2-chlolophenol
SMILES OC1=CC=C(I)C=C1Cl

Computational Chemistry Data

TPSA 20.23
LogP 2.6502
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Phenol

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

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2-Chloro-4-iodophenol

CAS No. 116130-33-7

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