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CS-W001157 4
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5-Methyl-6-oxo-1,6-dihydropyridine-2-carboxylic acid

  • CAS No. 115185-79-0

  • Cat. No. CS-W006932
  • Purity≥98%
  • MDL No.MFCD13174826

*For research and further manufacturing use only, not for direct human use.

5-Methyl-6-oxo-1,6-dihydropyridine-2-carboxylic acid|CS-W006932

Structure of 115185-79-0

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General Information

  • CAS No. 115185-79-0
  • Cat. No. CS-W006932
  • Purity ≥98%
  • MDL No. MFCD13174826
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇NO₃
  • Molecular Weight 153.14
  • Synonym(s) 2-Pyridinecarboxylicacid,1,6-dihydro-5-methyl-6-oxo-(9CI)
  • SMILES CC1=CC=C(NC1=O)C(O)=O

Description

This electron-deficient dihydropyridine derivative features a conjugated carbonyl and carboxylic acid moiety, enabling direct integration into heterocyclic synthesis. The methyl group at the 5-position enhances regioselectivity in cycloaddition reactions, while the bench-stable structure facilitates handling under standard conditions.

Application

5-Methyl-6-oxo-1,6-dihydropyridine-2-carboxylic acid serves as a versatile building block for heterocyclic synthesis, enabling efficient access to pyridine and dihydropyridine scaffolds. Its conjugated enone system and carboxylic acid functionality support diverse transformations, including nucleophilic additions, cyclizations, and metal-catalyzed couplings. The molecule exhibits bench stability and facilitates straightforward purification, making it well-suited for medicinal chemistry campaigns and process development workflows.

Synthesis

  • Route1
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      3060-68-2
    • ~%
    • In-stock
      5-Methyl-6-oxo-1,6-dihydropyridine-2-carboxylic acid|CS-W006932
      115185-79-0

    References

    • Konno; Hashimoto; Ohfune; Shirahama; Matsumoto Journal of the American Chemical Society, 1988 , vol. 110, # 14 p. 4807 - 4815

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   70.16
  • LogP   0.38152
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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