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CS-W001157 4
Total: USD 88.00

4-Methylmorpholine-2-carboxylic acid

  • CAS No. 842949-48-8

  • Cat. No. CS-0151064
  • Purity≥97%
  • MDL No.MFCD09997818

*For research and further manufacturing use only, not for direct human use.

4-Methylmorpholine-2-carboxylic acid|CS-0151064

Structure of 842949-48-8

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General Information

  • CAS No. 842949-48-8
  • Cat. No. CS-0151064
  • Purity ≥97%
  • MDL No. MFCD09997818
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₁NO₃
  • Molecular Weight 145.16
  • Synonym(s) 4-METHYL-MORPHOLINE-2-CARBOXYLIC ACID
  • SMILES CN1CCOC(C1)C(=O)O

Description

4-Methylmorpholine-2-carboxylic acid features a sterically hindered morpholine core with a carboxylic acid at the 2-position, enabling direct incorporation into peptide backbones or bioconjugation strategies. The methyl group enhances lipophilicity and metabolic stability, while the cyclic amine provides a rigid scaffold ideal for structural probing in medicinal chemistry. This compound serves as a key building block for constrained peptidomimetics and kinase inhibitor scaffolds.

Application

4-Methylmorpholine-2-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and peptide mimetics. Its constrained morpholine core provides enhanced metabolic stability and favorable solubility, while the carboxylic acid functionality facilitates direct coupling or derivatization in standard amide bond formation protocols. The molecule exhibits excellent bench stability and is compatible with diverse functional groups, making it well-suited for iterative synthetic campaigns and scale-up applications.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   49.77
  • LogP   -0.5984
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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