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CS-W001157 4
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2-(Tritylthio)ethanamine

  • CAS No. 1095-85-8

  • Cat. No. CS-0156531
  • Purity≥95%
  • MDL No.MFCD00822629

*For research and further manufacturing use only, not for direct human use.

2-(Tritylthio)ethanamine|CS-0156531

Structure of 1095-85-8

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General Information

  • CAS No. 1095-85-8
  • Cat. No. CS-0156531
  • Purity ≥95%
  • MDL No. MFCD00822629
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₁H₂₁NS
  • Molecular Weight 319.46
  • Synonym(s) S-Tritylcysteamine
  • SMILES C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)SCCN

Description

2-(Tritylthio)ethanamine features a trityl-protected thiol group that enables selective conjugation in peptide synthesis. This robust protecting group resists premature oxidation and cleaves cleanly under mild acidic conditions, delivering free thiols for downstream functionalization. The molecule’s hydrophobic trityl moiety enhances solubility in organic media while maintaining stability during standard coupling protocols.

Application

2-(Tritylthio)ethanamine serves as a robust sulfur-protecting group for thiols, enabling selective functionalization in complex molecule synthesis. The trityl (triphenylmethyl) moiety provides excellent steric shielding and facilitates easy removal under mild acidic conditions. Its stability under a range of reaction conditions—oxidative, reductive, and nucleophilic—makes it ideal for multi-step sequences, particularly in peptide and oligonucleotide derivatization.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   4.6704
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   6

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