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CS-W001157 4
Total: USD 88.00

4-Chloro-(2-trifluoromethyl)pyridine

  • CAS No. 131748-14-6

  • Cat. No. CS-W006253
  • Purity≥98%
  • MDL No.MFCD07368047

*For research and further manufacturing use only, not for direct human use.

4-Chloro-(2-trifluoromethyl)pyridine|CS-W006253

Structure of 131748-14-6

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General Information

  • CAS No. 131748-14-6
  • Cat. No. CS-W006253
  • Purity ≥98%
  • MDL No. MFCD07368047
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃ClF₃N
  • Molecular Weight 181.54
  • Synonym(s) 4-Chloro-2-(Trifluoromethyl)pyridine
  • SMILES FC(C1=NC=CC(Cl)=C1)(F)F

Description

DSPE-SPDP is a phospholipid molecule which can orient itself to form lipid bilayer in water. The hydrophobic tails will face inner part while the hydrophilic head faces outward and interacts with water. The SPDP moiety is reactive with thiol molecule to form a disulfide bond.

Application

4-Chloro-2-(trifluoromethyl)pyridine serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions due to its well-established reactivity at the C4 position. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the pyridine core provides a robust platform for further functionalization. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for modular scaffold construction in industrial R&D workflows.

Synthesis

  • Route1

    References

    • WO2011/161612 A1, ; Page/Page column 13 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2810
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.7538
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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