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CS-W001157 4
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DMT-dU-CE Phosphoramidite

  • CAS No. 109389-30-2

  • Cat. No. CS-0149454
  • Purity≥98%
  • MDL No.MFCD00036354

*For research and further manufacturing use only, not for direct human use.

DMT-dU-CE Phosphoramidite|CS-0149454

Structure of 109389-30-2

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General Information

  • CAS No. 109389-30-2
  • Cat. No. CS-0149454
  • Purity ≥98%
  • MDL No. MFCD00036354
  • Storage -20°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃₉H₄₇N₄O₈P
  • Molecular Weight 730.79
  • Synonym(s) None
  • SMILES COC(C=C1)=CC=C1C(C2=CC=C(C=C2)OC)(C3=CC=CC=C3)OC[C@@H]4[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)C[C@H](N5C(NC(C=C5)=O)=O)O4

Description

DMT-dU-CE Phosphoramidite delivers a protected uridine derivative with a 5'-dimethoxytrityl group and a 3'-cholesteryl ether linkage, enabling efficient incorporation into oligonucleotides. The cholesteryl moiety enhances duplex stability through hydrophobic interactions, while the DMT group ensures convenient purification and monitoring. This reagent supports robust synthesis under standard conditions.

Application

DMT-dU-CE Phosphoramidite serves as a key building block for the site-specific incorporation of 5-(2-cyanoethyl)-2'-deoxyuridine into oligonucleotides during solid-phase synthesis. Its cyanoethyl protecting group enables efficient deprotection under mild basic conditions, ensuring high fidelity and minimal side reactions. The dimethoxytrityl (DMT) group provides excellent UV monitoring and facilitates purification via chromatography. This phosphoramidite exhibits robust stability, predictable coupling efficiency, and broad compatibility with standard synthesis protocols, making it ideal for the preparation of modified DNA sequences in research and diagnostics.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H319-H332
Precautionary Statements : P261-P264-P270-P271-P280-P301+P310-P302+P352-P304+P341-P305+P351+P338-P312-P330-P337+P313-P363-P501

Quality Control

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Computational Chemistry Data

  • TPSA   137.27
  • LogP   6.51118
  • H_Acceptors   11
  • H_Donors   1
  • Rotatable_Bonds   17

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