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Structure of 386704-06-9
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2-Chloro-6-(trifluoromethyl)nicotinonitrile features a trifluoromethyl group that enhances electron deficiency and metabolic stability, while the cyano and chloro substituents enable direct functionalization in heterocyclic synthesis. This bench-stable building block integrates efficiently into pharmaceutical intermediates and agrochemical scaffolds under standard conditions.
2-Chloro-6-(trifluoromethyl)nicotinonitrile serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles via palladium-catalyzed cross-coupling reactions. Its trifluoromethyl and nitrile groups provide strong electron-withdrawing character, enhancing reactivity in nucleophilic substitution and facilitating functionalization at the 2-position. The compound exhibits excellent bench stability and compatibility with standard synthetic protocols, making it ideal for modular synthesis of pharmaceutical intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: