Lot numbers can be found on the outside label of a product:
Quinoline-6-sulfonyl chloride
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CAS No. 65433-99-0
- Cat. No. CS-0262579
- Purity≥95%
- MDL No.MFCD03086095
*For research and further manufacturing use only, not for direct human use.
Structure of 65433-99-0
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General Information
- CAS No. 65433-99-0
- Cat. No. CS-0262579
- Purity ≥95%
- MDL No. MFCD03086095
- Storage -20°C, stored under nitrogen, away from moisture
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₉H₆ClNO₂S
- Molecular Weight None
- Synonym(s) 6-QUINOLINESULFONYLCHLORIDE
- SMILES C1=CC2=CC(=CC=C2N=C1)S(=O)(=O)Cl
Description
Quinoline-6-sulfonyl chloride serves as a reactive acylating agent for amine functionalization, enabling direct installation of a quinoline-based sulfonyl group. This moiety enhances solubility and provides a rigid, electron-deficient scaffold useful in medicinal chemistry and fluorescent probe design. The reagent exhibits high stability under standard conditions and facilitates efficient coupling without requiring additional activators.
Application
Quinoline-6-sulfonyl chloride serves as a versatile building block for the synthesis of sulfonamide-containing heterocycles, enabling efficient introduction of a sulfonyl group at the C6 position of quinoline. Its reactivity facilitates nucleophilic substitution with amines and alcohols under mild conditions, offering high functional group tolerance and ease of purification. The resulting sulfonamides are valuable intermediates in medicinal chemistry and catalytic system design.
Synthesis
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Route1
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100653-59-6 - ~86%
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In-stock
65433-99-0
References
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Maslankiewicz, Andrzej; Marciniec, Krzysztof; Pawlowski, Maciej; Zajdel, Pawel Heterocycles, 2007 , vol. 71, # 9 p. 1975 - 1990
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Route2
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1160-97-0 - ~%
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In-stock
65433-99-0
References
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Journal of Molecular Structure, , vol. 1015, p. 46 - 50
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Route3
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65433-95-6 - ~%
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In-stock
65433-99-0
References
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Farmaco, Edizione Scientifica, , vol. 9, p. 459,463,464 Zhurnal Obshchei Khimii, , vol. 28, p. 1003,1005; engl. Ausg. S. 976, 978
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 1759
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H314
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Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 47.03
- LogP 2.1623
- H_Acceptors 3
- H_Donors 0
- Rotatable_Bonds 1
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Key Words
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