Lot numbers can be found on the outside label of a product:
Quinoline-7-sulfonyl chloride
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CAS No. 443692-93-1
- Cat. No. CS-0452596
- Purity≥95%
- MDL No.None
*For research and further manufacturing use only, not for direct human use.
Structure of 443692-93-1
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General Information
- CAS No. 443692-93-1
- Cat. No. CS-0452596
- Purity ≥95%
- MDL No. None
- Storage 4°C, sealed storage, away from moisture
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₉H₆ClNO₂S
- Molecular Weight 227.67
- Synonym(s) Quinolin-7-sulfonyl chloride
- SMILES C1=CC2=C(C=C(C=C2)S(=O)(=O)Cl)N=C1
Description
Quinoline-7-sulfonyl chloride serves as a reactive acylating agent for introducing sulfonamide functionalities into organic frameworks. The quinoline moiety enhances solubility and provides a rigid, electron-deficient scaffold ideal for conjugation in pharmaceutical intermediates. This reagent offers high functional group tolerance and reacts efficiently under mild conditions, enabling streamlined synthesis of bioactive molecules.
Application
Quinoline-7-sulfonyl chloride serves as a versatile acylating agent for amine functionalization, enabling efficient synthesis of sulfonamide derivatives under mild conditions. Its quinoline moiety enhances solubility and facilitates purification, while the sulfonyl chloride group exhibits high reactivity toward primary and secondary amines. The compound demonstrates excellent bench stability and functional group tolerance, making it well-suited for use in medicinal chemistry campaigns and the construction of heterocyclic scaffolds via direct amidation or subsequent derivatization.
Synthesis
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Route1
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157767-42-5 - ~85%
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In-stock
443692-93-1
References
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Maslankiewicz, Andrzej; Marciniec, Krzysztof; Pawlowski, Maciej; Zajdel, Pawel Heterocycles, 2007 , vol. 71, # 9 p. 1975 - 1990
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Route2
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109558-83-0
- ~%
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In-stock
443692-93-1
References
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Marciniec, Krzysztof; Maslankiewicz, Andrzej; Maslankiewicz, Maria J.; Kurczab, Rafal Journal of Molecular Structure, 2012 , vol. 1015, p. 46 - 50
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Route3
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In-stock
4965-36-0 - ~%
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In-stock
443692-93-1
References
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Zajdel, Pawel; Marciniec, Krzysztof; Maslankiewicz, Andrzej; Grychowska, Katarzyna; Satala, Grzegorz; Duszynska, Beata; Lenda, Tomasz; Siwek, Agata; Nowak, Gabriel; Partyka, Anna; Wrobel, Dagmara; Jastrzebska-Wiesek, Magdalena; Bojarski, Andrzej J.; Wesolowska, Anna; Pawlowski, MacIej European Journal of Medicinal Chemistry, 2013 , vol. 60, p. 42 - 50
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H314
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Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 47.03
- LogP 2.1623
- H_Acceptors 3
- H_Donors 0
- Rotatable_Bonds 1
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Key Words
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