Ethyl 4-amino-6-chloro-5-fluoronicotinate

Name: Ethyl 4-amino-6-chloro-5-fluoronicotinate
Brand: ChemScene
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CAS No. 2454397-74-9
Cat. No. CS-0148204
Purity≥98%
MDL No.MFCD34471315

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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Ethyl 4-amino-6-chloro-5-fluoronicotinate|CS-0148204

Structure of 2454397-74-9

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General Information

CAS No. 2454397-74-9
Cat. No. CS-0148204
Purity ≥98%
MDL No. MFCD34471315
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₈ClFN₂O₂
Molecular Weight 218.62
Synonym(s) Ethyl 4-amino-6-chloro-5-fluoropyridine-3-carboxylate
SMILES O=C(C1=C(N)C(F)=C(Cl)N=C1)OCC

Description

Ethyl 4-amino-6-chloro-5-fluoronicotinate features a fluorinated pyridine core with complementary electron-withdrawing chlorine and amino substituents, enabling selective coupling reactions in medicinal chemistry. The ester handle facilitates downstream derivatization, while the para-fluoro and ortho-chloro groups enhance reactivity and metabolic stability in bioactive molecule synthesis.

Application

Ethyl 4-amino-6-chloro-5-fluoronicotinate serves as a versatile building block in the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its electron-deficient pyridine core, combined with orthogonal functional groups—namely the amino, chloro, fluoro, and ester moieties—enables selective transformations under standard coupling and substitution conditions. The compound exhibits bench stability, facilitates efficient purification, and functions reliably in multi-step syntheses targeting kinase inhibitors and other medicinal chemistry scaffolds.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

TPSA 65.21
LogP 1.633
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Chloride

Building Blocks Functional Group Ester

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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Ethyl 4-amino-6-chloro-5-fluoronicotinate

CAS No. 2454397-74-9

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