3-Bromo-5-chloropyridine

Name: 3-Bromo-5-chloropyridine
Brand: ChemScene
Availability: InStock
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CAS No. 73583-39-8
Cat. No. CS-W003165
Purity≥98%
MDL No.MFCD04114221

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 73583-39-8
Cat. No. CS-W003165
Purity ≥98%
MDL No. MFCD04114221
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₃BrClN
Molecular Weight 192.44
Synonym(s) None
SMILES ClC1=CN=CC(Br)=C1

Description

3-Bromo-5-chloropyridine is a halogenated pyridine derivative featuring complementary reactive sites for cross-coupling and functionalization. This electron-deficient heterocycle enables selective transformations in medicinal chemistry and materials synthesis, offering robust stability under standard conditions.

Application

3-Bromo-5-chloropyridine serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The bromo group facilitates efficient Suzuki, Stille, or Negishi couplings, while the chloro substituent offers orthogonal reactivity for sequential functionalization. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for constructing complex heterocyclic scaffolds and API intermediates.

Synthesis

Route1
- In-stock
  
  26163-03-1
- ~%
- In-stock
  
  73583-39-8
References
- Tetrahedron, , vol. 60, # 51 p. 11869 - 11874
Route2
- In-stock
  
  137628-17-2
- ~%
- In-stock
  
  73583-39-8
- In-stock
  
  823221-97-2
References
- Tetrahedron, , vol. 60, # 51 p. 11869 - 11874

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05,GHS06
Signal Word : Danger	UN#: 2811
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H301-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 12.89
LogP 2.4975
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Bioactive Molecules Dye and Bio-assay Reagents

Building Blocks Functional Group Chloride

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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3-Bromo-5-chloropyridine

CAS No. 73583-39-8

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