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CS-W001157 4
Total: USD 88.00

5-Bromo-2,3-dichloropyridine

  • CAS No. 97966-00-2

  • Cat. No. CS-W008582
  • Purity≥98%
  • MDL No.MFCD04112492

*For research and further manufacturing use only, not for direct human use.

5-Bromo-2,3-dichloropyridine|CS-W008582

Structure of 97966-00-2

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General Information

  • CAS No. 97966-00-2
  • Cat. No. CS-W008582
  • Purity ≥98%
  • MDL No. MFCD04112492
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂BrCl₂N
  • Molecular Weight 226.89
  • Synonym(s) 5-Brom-2,3-dichlorpyridin
  • SMILES ClC1=CC(Br)=CN=C1Cl

Description

5-Bromo-2,3-dichloropyridine features a highly reactive pyridine core bearing bromo and dichloro substituents at regioselective positions, enabling efficient cross-coupling and functionalization. This electron-deficient heterocycle integrates readily into pharmaceutical intermediates and agrochemical scaffolds under standard conditions.

Application

5-Bromo-2,3-dichloropyridine serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The bromo group facilitates Suzuki, Stille, or Negishi coupling under standard conditions, while the chloro substituents offer stability and selective functionalization potential. This compound exhibits excellent bench stability, ease of handling, and compatibility with common protecting groups, making it ideal for modular scaffold construction in multi-step syntheses.

Synthesis

  • Route1

    References

    • US2004/242644 A1, ; Page 4 ;
  • Route2

    References

    • Journal of the Chemical Society, , p. 2042,2044
  • Route3

    References

    • Journal of the Chemical Society, , p. 2042,2044

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   3.1509
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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