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CS-W001157 4
Total: USD 88.00

2,6-Dichloro-3-bromopyridine

  • CAS No. 866755-20-6

  • Cat. No. CS-W014700
  • Purity≥96%
  • MDL No.MFCD06798231

*For research and further manufacturing use only, not for direct human use.

2,6-Dichloro-3-bromopyridine|CS-W014700

Structure of 866755-20-6

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General Information

  • CAS No. 866755-20-6
  • Cat. No. CS-W014700
  • Purity ≥96%
  • MDL No. MFCD06798231
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂BrCl₂N
  • Molecular Weight 226.88
  • Synonym(s) Pyridine, 3-bromo-2,6-dichloro-
  • SMILES BrC1=CC=C(N=C1Cl)Cl

Description

2,6-Dichloro-3-bromopyridine features a highly reactive pyridine core substituted with chlorine and bromine atoms at electron-deficient positions. This configuration enables selective cross-coupling transformations under mild conditions, facilitating efficient access to functionalized heterocycles in medicinal chemistry and materials science applications.

Application

2,6-Dichloro-3-bromopyridine serves as a versatile building block in medicinal chemistry and heterocyclic synthesis, enabling selective Suzuki-Miyaura and Buchwald-Hartwig couplings due to its orthogonal halogen reactivity. The dichloro substitution pattern enhances electrophilicity at C3, facilitating nucleophilic displacement reactions, while the bromine moiety offers high compatibility with palladium-catalyzed transformations. Bench-stable and readily purified by distillation, it functions effectively in multi-step synthetic sequences requiring regioselective functionalization.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H315-H318-H335
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   3.1509
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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