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CS-W001157 4
Total: USD 88.00

4-Chloro-6-methoxynicotinic acid

  • CAS No. 1060806-60-1

  • Cat. No. CS-0372925
  • Purity≥98%
  • MDL No.MFCD13188727

*For research and further manufacturing use only, not for direct human use.

4-Chloro-6-methoxynicotinic acid|CS-0372925

Structure of 1060806-60-1

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General Information

  • CAS No. 1060806-60-1
  • Cat. No. CS-0372925
  • Purity ≥98%
  • MDL No. MFCD13188727
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆ClNO₃
  • Molecular Weight 187.58
  • Synonym(s) 4-Chloro-6-methoxypyridine-3-carboxylic acid
  • SMILES O=C(C1=C(Cl)C=C(OC)N=C1)O

Description

4-Chloro-6-methoxynicotinic acid features a strategically positioned chloro group and methoxy substituent on the nicotinic acid scaffold, enabling precise tuning of electronic properties and solubility. This configuration supports efficient integration into bioactive scaffolds and synthetic intermediates requiring balanced polarity and metabolic stability under standard conditions.

Application

4-Chloro-6-methoxynicotinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-chloro and meta-methoxy substituents provide orthogonal reactivity for palladium-catalyzed couplings and selective derivatization. The carboxylic acid functionality facilitates amide formation and esterification, while the compound exhibits good bench stability and ease of purification, making it well-suited for scalable synthesis workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   59.42
  • LogP   1.4418
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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