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CS-W001157 4
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4-Chloro-2-methoxynicotinic acid

  • CAS No. 605661-81-2

  • Cat. No. CS-0042692
  • Purity≥98%
  • MDL No.MFCD13188728

*For research and further manufacturing use only, not for direct human use.

4-Chloro-2-methoxynicotinic acid|CS-0042692

Structure of 605661-81-2

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General Information

  • CAS No. 605661-81-2
  • Cat. No. CS-0042692
  • Purity ≥98%
  • MDL No. MFCD13188728
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆ClNO₃
  • Molecular Weight 187.58
  • Synonym(s) 4-chloro-2-Methoxy-pyridine-3-carboxylic acid
  • SMILES O=C(O)C1=C(OC)N=CC=C1Cl

Description

4-Chloro-2-methoxynicotinic acid features a strategically positioned chloro group and methoxy substituent on the nicotinic acid scaffold, enabling precise tuning of electronic properties and solubility. This configuration supports efficient coupling in synthetic routes to bioactive heterocycles and pharmaceutical intermediates under standard conditions.

Application

4-Chloro-2-methoxynicotinic acid serves as a versatile building block for heterocyclic synthesis, particularly in the construction of pyridine and quinoline derivatives. Its ortho-methoxy and meta-chloro substituents enable selective functionalization and compatibility with palladium-catalyzed cross-coupling reactions. The carboxylic acid group facilitates direct amidation or esterification, while the molecule exhibits good bench stability and ease of purification, making it well-suited for medicinal chemistry and process development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   59.42
  • LogP   1.4418
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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