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CS-W001157 4
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5-Chloro-2-methoxynicotinic acid

  • CAS No. 54916-65-3

  • Cat. No. CS-0053941
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Chloro-2-methoxynicotinic acid|CS-0053941

Structure of 54916-65-3

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General Information

  • CAS No. 54916-65-3
  • Cat. No. CS-0053941
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆ClNO₃
  • Molecular Weight 187.58
  • Synonym(s) 5-chloro-2-methoxypyridine-3-carboxylic acid
  • SMILES O=C(O)C1=C(OC)N=CC(Cl)=C1

Description

5-Chloro-2-methoxynicotinic acid is a bench-stable, electron-deficient heterocyclic building block featuring a chlorinated pyridine core and a methoxy-substituted carboxylic acid. This combination enables direct incorporation into pharmaceutical intermediates and agrochemical scaffolds through coupling reactions, offering enhanced reactivity and metabolic stability in complex synthesis workflows.

Application

5-Chloro-2-methoxynicotinic acid serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-methoxy and meta-chloro substituents enable selective functionalization and compatibility with standard coupling reactions, facilitating efficient access to complex scaffolds. The compound exhibits good bench stability and is readily purified by recrystallization, supporting reliable use in multi-step synthetic sequences.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   59.42
  • LogP   1.4418
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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