Methyl 4-chloro-6-methoxynicotinate

Name: Methyl 4-chloro-6-methoxynicotinate
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CAS No. 848953-45-7
Cat. No. CS-0102117
Purity≥97%
MDL No.MFCD18257745

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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Methyl 4-chloro-6-methoxynicotinate|CS-0102117

Structure of 848953-45-7

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General Information

CAS No. 848953-45-7
Cat. No. CS-0102117
Purity ≥97%
MDL No. MFCD18257745
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₈ClNO₃
Molecular Weight 201.61
Synonym(s) 4-Chloro-6-methoxy-nicotinic acid methyl ester
SMILES O=C(C1=CN=C(C=C1Cl)OC)OC

Description

Methyl 4-chloro-6-methoxynicotinate is a bench-stable, electron-deficient heterocyclic ester featuring a para-chloro and ortho-methoxy substitution on the pyridine ring. This configuration enhances reactivity in cross-coupling processes and enables direct incorporation into complex molecular architectures. The methoxynicotinate motif provides solubility in common organic solvents and facilitates downstream functionalization via nucleophilic displacement or metal-mediated transformations.

Application

Methyl 4-chloro-6-methoxynicotinate serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted pyridine derivatives. The chloro group at the 4-position facilitates nucleophilic aromatic substitution, while the methoxy and ester functionalities offer orthogonal reactivity for downstream transformations. Its bench-stable nature and compatibility with standard coupling reactions make it well-suited for medicinal chemistry and process development workflows.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

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Computational Chemistry Data

TPSA 48.42
LogP 1.5302
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Ester

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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Methyl 4-chloro-6-methoxynicotinate

CAS No. 848953-45-7

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