4-Bromo-1-(tetrahydrofuran-3-yl)-1H-pyrazole

Name: 4-Bromo-1-(tetrahydrofuran-3-yl)-1H-pyrazole
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1040377-07-8
Cat. No. CS-0135514
Purity≥97%
MDL No.MFCD18366437

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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4-Bromo-1-(tetrahydrofuran-3-yl)-1H-pyrazole|CS-0135514

Structure of 1040377-07-8

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General Information

CAS No. 1040377-07-8
Cat. No. CS-0135514
Purity ≥97%
MDL No. MFCD18366437
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₉BrN₂O
Molecular Weight 217.06
Synonym(s) None
SMILES BrC1=CN(C2COCC2)N=C1

Description

4-Bromo-1-(tetrahydrofuran-3-yl)-1H-pyrazole integrates a brominated pyrazole core with a tetrahydrofuran-3-yl substituent, offering a bench-stable scaffold for constructing diverse heterocyclic libraries. The electron-deficient pyrazole ring pairs with the chiral tetrahydrofuran moiety to enable stereoselective coupling reactions and facilitate access to bioactive compounds in medicinal chemistry.

Application

4-Bromo-1-(tetrahydrofuran-3-yl)-1H-pyrazole serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its stable bromo functionality. The tetrahydrofuran-3-yl group provides enhanced solubility and metabolic stability, while the pyrazole core offers a rigid, polar scaffold for target engagement. Its bench-stable nature and compatibility with standard reaction conditions facilitate efficient synthesis of diverse heterocyclic architectures.

Synthesis

Route1
- In-stock
  
  2075-45-8
- 156380-34-6
- ~81%
- In-stock
  
  1040377-07-8
References
- XCOVERY, INC. Patent: WO2008/88881 A1, 2008 ; Location in patent: Page/Page column 46 ; WO 2008/088881 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

TPSA 27.05
LogP 1.607
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Tetrahydrofuran compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Key Words

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4-Bromo-1-(tetrahydrofuran-3-yl)-1H-pyrazole

CAS No. 1040377-07-8

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