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CS-W001157 4
Total: USD 88.00

5-Bromo-2-methyl-3-(trifluoromethyl)pyridine

  • CAS No. 1211526-51-0

  • Cat. No. CS-0153530
  • Purity≥97%
  • MDL No.MFCD18257687

*For research and further manufacturing use only, not for direct human use.

5-Bromo-2-methyl-3-(trifluoromethyl)pyridine|CS-0153530

Structure of 1211526-51-0

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General Information

  • CAS No. 1211526-51-0
  • Cat. No. CS-0153530
  • Purity ≥97%
  • MDL No. MFCD18257687
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅BrF₃N
  • Molecular Weight 240.02
  • Synonym(s) None
  • SMILES CC1=C(C=C(C=N1)Br)C(F)(F)F

Description

5-Bromo-2-methyl-3-(trifluoromethyl)pyridine features a trifluoromethyl group that imparts enhanced electron-withdrawing character and metabolic stability. The bromine substituent enables facile palladium-catalyzed cross-coupling, while the methyl group provides steric control. This combination facilitates efficient integration into complex heterocyclic scaffolds under standard conditions.

Application

5-Bromo-2-methyl-3-(trifluoromethyl)pyridine serves as a versatile building block in medicinal chemistry and catalytic cross-coupling reactions. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the bromo and methyl substituents enable selective functionalization via Pd-catalyzed couplings. The compound exhibits good bench stability and facilitates efficient access to substituted pyridine scaffolds common in agrochemicals and pharmaceuticals.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   3.17132
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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