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2-({[(9h-fluoren-9-yl)methoxy]carbonyl}(prop-2-yn-1-yl)amino)acetic acid

  • CAS No. 1033622-38-6

  • Cat. No. CS-0217669
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-({[(9h-fluoren-9-yl)methoxy]carbonyl}(prop-2-yn-1-yl)amino)acetic acid|CS-0217669

Structure of 1033622-38-6

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General Information

  • CAS No. 1033622-38-6
  • Cat. No. CS-0217669
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₀H₁₇NO₄
  • Molecular Weight 335.35
  • Synonym(s) Fmoc-N-(propargyl)-glycine
  • SMILES C#CCN(CC(=O)O)C(=O)OCC1C2=CC=CC=C2C3=CC=CC=C31

Description

This fluorenylmethoxycarbonyl-protected amino acid derivative features a propargylamine handle enabling efficient copper-catalyzed azide-alkyne cycloaddition. The orthogonal functionality supports site-specific conjugation in peptide synthesis and bioconjugation workflows. Bench-stable under standard conditions, it integrates seamlessly into solid-phase protocols for modular peptide assembly.

Application

2-({[(9H-fluoren-9-yl)methoxy]carbonyl}(prop-2-yn-1-yl)amino)acetic acid serves as a versatile protected amino acid building block for peptide synthesis, combining the robustness of Fmoc (fluoren-9-ylmethoxycarbonyl) protection with a propargylamine side chain. The alkyne functionality enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC), facilitating site-specific conjugation and diversity-oriented synthesis. Bench-stable and compatible with standard coupling protocols, it supports reliable purification and integration into complex peptide architectures.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   2.9553
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   5

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