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CS-W001157 4
Total: USD 88.00

4-(4-Aminophenoxy)pyridine

  • CAS No. 102877-78-1

  • Cat. No. CS-B0030
  • Purity≥98%
  • MDL No.MFCD06825431

*For research and further manufacturing use only, not for direct human use.

4-(4-Aminophenoxy)pyridine|CS-B0030

Structure of 102877-78-1

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General Information

  • CAS No. 102877-78-1
  • Cat. No. CS-B0030
  • Purity ≥98%
  • MDL No. MFCD06825431
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₀N₂O
  • Molecular Weight 186.21
  • Synonym(s) IFLAB-BB F2108-0079
  • SMILES NC1=CC=C(C=C1)OC2=CC=NC=C2

Description

4-(4-Aminophenoxy)pyridine features a pyridine ring linked via an ether bridge to a para-aminophenyl group, combining basic nitrogen functionality with extended conjugation. This scaffold enables integration into pharmaceutical intermediates and functional materials, offering enhanced solubility and tunable electronic properties for medicinal chemistry applications.

Application

4-(4-Aminophenoxy)pyridine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocyclic scaffolds through standard coupling reactions. Its pyridine core provides a hydrogen-bond acceptor site and enhances solubility, while the aniline and phenoxy functionalities offer orthogonal reactivity for derivatization. The compound exhibits good bench stability and is compatible with common purification methods, facilitating integration into multi-step syntheses of pharmaceutical candidates.

Synthesis

  • Route1

    References

    • MERCK PATENT GmbH Patent: WO2005/4863 A1, 2005 ; Location in patent: Page/Page column 127-128 ; WO 2005/004863 A1
  • Route2
    • In-stock
      4-Chloropyridine hydrochloride|CS-W019791
      7379-35-3
    • null|null
      123-30-8
    • ~96%
    • In-stock
      4-(4-Aminophenoxy)pyridine|CS-B0030
      102877-78-1

    References

    • Borzilleri, Robert M.; Cornelius, Lyndon A.M.; Schmidt, Robert J.; Schroeder, Gretchen M.; Kim, Kyoung S. Patent: US2005/245530 A1, 2005 ; Location in patent: Page/Page column 23 ; US 20050245530 A1
  • Route3
    • null|null
      100-02-7
    • ~%
    • In-stock
      4-(4-Aminophenoxy)pyridine|CS-B0030
      102877-78-1

    References

    • Pharmaceutical Bulletin, , vol. 1, p. 70,73

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   2.4561
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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