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CS-W001157 4
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Azetidine-3-carboxylic acid hydrochloride

  • CAS No. 102624-96-4

  • Cat. No. CS-0067915
  • Purity≥97%
  • MDL No.MFCD06796562

*For research and further manufacturing use only, not for direct human use.

Azetidine-3-carboxylic acid hydrochloride|CS-0067915

Structure of 102624-96-4

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General Information

  • CAS No. 102624-96-4
  • Cat. No. CS-0067915
  • Purity ≥97%
  • MDL No. MFCD06796562
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₈ClNO₂
  • Molecular Weight 137.56
  • Synonym(s) Azetidine-3-carboxylic acid??????HCl
  • SMILES O=C(C1CNC1)O.[H]Cl

Description

Azetidine-3-carboxylic acid hydrochloride is a conformationally constrained, nitrogen-rich heterocycle featuring a strained four-membered ring that imparts rigidity to peptide backbones. This scaffold integrates readily into bioactive molecules, enhancing metabolic stability and modulating target affinity through defined spatial orientation. The hydrochloride salt improves solubility and handling under standard bench conditions.

Application

Azetidine-3-carboxylic acid hydrochloride serves as a conformationally constrained proline analog, enabling the stabilization of bioactive peptide conformations. Its four-membered ring structure facilitates backbone rigidity in peptidomimetics, while the carboxylic acid group supports direct coupling reactions. The hydrochloride salt enhances bench stability and solubility, simplifying handling and purification in solid-phase and solution-phase synthesis.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   49.33
  • LogP   -0.2878
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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