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CS-W001157 4
Total: USD 88.00

3-Azetidinemethanol hydrochloride

  • CAS No. 928038-44-2

  • Cat. No. CS-D1756
  • Purity≥97%
  • MDL No.MFCD09743446

*For research and further manufacturing use only, not for direct human use.

3-Azetidinemethanol hydrochloride|CS-D1756

Structure of 928038-44-2

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General Information

  • CAS No. 928038-44-2
  • Cat. No. CS-D1756
  • Purity ≥97%
  • MDL No. MFCD09743446
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₁₀ClNO
  • Molecular Weight 123.58
  • Synonym(s) None
  • SMILES OCC1CNC1.Cl

Description

3-Azetidinemethanol (hydrochloride) delivers a reactive azetidine core with a pendant hydroxymethyl group, enabling direct functionalization in medicinal chemistry. This bench-stable, moisture-tolerant scaffold integrates readily into target-oriented synthesis, offering enhanced solubility and metabolic stability for bioactive molecule design.

Application

3-Azetidinemethanol (hydrochloride) serves as a versatile building block for the synthesis of bioactive heterocycles, particularly in medicinal chemistry applications. Its primary amine functionality enables straightforward derivatization, while the hydrochloride salt enhances stability and solubility for handling. The molecule functions effectively in nucleophilic substitution reactions and facilitates the construction of pyrrolidine-containing scaffolds via cyclization protocols. Its bench-stable nature and compatibility with standard coupling conditions make it well-suited for iterative synthesis workflows.

Synthesis

  • Route1
    • (1-Benzhydrylazetidin-3-yl)methanol|CS-0046194
      72351-36-1
    • ~%
    • In-stock
      3-Azetidinemethanol hydrochloride|CS-D1756
      928038-44-2

    References

    • EP1889836 A1, ; Page/Page column 84 ;
  • Route2
    • (1-Benzylazetidin-3-yl)methanol|CS-0318947
      99025-94-2
    • ~83%
    • In-stock
      3-Azetidinemethanol hydrochloride|CS-D1756
      928038-44-2

    References

    • INDUSTRIAL RESEARCH LIMITED; ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY Patent: WO2008/79028 A1, 2008 ; Location in patent: Page/Page column 15; 17 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   32.26
  • LogP   -0.3801
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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