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CS-W001157 4
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3-(Methoxymethyl)azetidine hydrochloride

  • CAS No. 942308-06-7

  • Cat. No. CS-W023140
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-(Methoxymethyl)azetidine hydrochloride|CS-W023140

Structure of 942308-06-7

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General Information

  • CAS No. 942308-06-7
  • Cat. No. CS-W023140
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₂ClNO
  • Molecular Weight 137.61
  • Synonym(s) 3-(Methoxymethyl)azetidine HCl
  • SMILES Cl.COCC1CNC1

Description

This bench-stable azetidine derivative features a methoxymethyl substituent that enhances solubility and metabolic stability. The hydrochloride salt form improves crystallinity and handling, enabling straightforward incorporation into medicinal chemistry campaigns for targeted kinase inhibition and CNS drug discovery.

Application

3-(Methoxymethyl)azetidine hydrochloride serves as a versatile building block in medicinal chemistry, offering a constrained azetidine core with a readily manipulable methoxymethyl side chain. The compound exhibits good bench stability and functional group tolerance, enabling efficient derivatization via ether cleavage or further functionalization. Its hydrochloride salt form enhances solubility and handling, facilitating incorporation into diverse synthetic routes for targeted API development.

Synthesis

  • Route1
    • tert-Butyl 3-(methoxymethyl)azetidine-1-carboxylate|CS-0079189
      942308-05-6
    • ~%
    • In-stock
      3-(Methoxymethyl)azetidine hydrochloride|CS-W023140
      942308-06-7

    References

    • EP1961750 A1, ; Page/Page column 90 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   0.274
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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