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CS-W001157 4
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Azetidine-3-carbonitrile hydrochloride

  • CAS No. 345954-83-8

  • Cat. No. CS-W018612
  • Purity≥97%
  • MDL No.MFCD09749828

*For research and further manufacturing use only, not for direct human use.

Azetidine-3-carbonitrile hydrochloride|CS-W018612

Structure of 345954-83-8

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General Information

  • CAS No. 345954-83-8
  • Cat. No. CS-W018612
  • Purity ≥97%
  • MDL No. MFCD09749828
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₇ClN₂
  • Molecular Weight 118.57
  • Synonym(s) 3-Azetidinecarbonitrile HCl
  • SMILES N#CC1CNC1.[H]Cl

Description

Azetidine-3-carbonitrile hydrochloride delivers a strained, electron-deficient azetidine ring fused to a nitrile group, enabling direct incorporation into bioactive molecules. This bench-stable salt features enhanced solubility and handling ease, streamlining synthetic workflows in medicinal chemistry.

Application

Azetidine-3-carbonitrile hydrochloride serves as a versatile building block in medicinal chemistry, enabling efficient access to nitrogen-containing heterocycles. Its strained azetidine ring enhances reactivity for nucleophilic functionalization, while the nitrile group offers direct utility in amidation, reduction, or cyclization reactions. The hydrochloride salt ensures excellent bench stability and solubility, facilitating straightforward handling and purification in standard synthetic workflows.

Synthesis

  • Route1

    References

    • WO2006/15854 A2, ; Page/Page column 17 ; WO 2006/015854 A2
  • Route2

    References

    • WO2010/60952 A1, ; Page/Page column 107-108 ; WO 2010/060952 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.82
  • LogP   0.15118
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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