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CS-W001157 4
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1-Cbz-Azetidine-3-CH2NH2

  • CAS No. 1016731-24-0

  • Cat. No. CS-0049855
  • Molecule weight220.27
  • Purity≥97%
  • MDL No.MFCD07772065

*For research and further manufacturing use only, not for direct human use.

1-Cbz-Azetidine-3-CH2NH2|CS-0049855

Structure of 1016731-24-0

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General Information

  • CAS No. 1016731-24-0
  • Cat. No. CS-0049855
  • Purity ≥97%
  • MDL No. MFCD07772065
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₆N₂O₂
  • Molecular Weight 220.27
  • Synonym(s) None
  • SMILES O=C(OCC=1C=CC=CC1)N2CC(CN)C2

Description

Benzyl 3-(aminomethyl)azetidine-1-carboxylate features a strained azetidine core with a pendant aminomethyl group, enabling direct functionalization. This bench-stable, moisture-tolerant reagent integrates readily into peptide-like scaffolds and serves as a key building block for bioactive molecule synthesis.

Application

Benzyl 3-(aminomethyl)azetidine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling efficient access to azetidine-containing scaffolds. The benzyloxycarbonyl (Cbz) group provides stable protection of the primary amine, facilitating orthogonal functionalization and simplifying purification. Its aminomethyl side chain undergoes standard transformations—such as alkylation, acylation, and reductive amination—while maintaining compatibility with diverse coupling reactions and heterocycle formation protocols common in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   55.56
  • LogP   1.2137
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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