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CS-W001157 4
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Azetidin-3-ylmethanamine dihydrochloride

  • CAS No. 221095-80-3

  • Cat. No. CS-W022574
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Azetidin-3-ylmethanamine dihydrochloride|CS-W022574

Structure of 221095-80-3

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General Information

  • CAS No. 221095-80-3
  • Cat. No. CS-W022574
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₁₂Cl₂N₂
  • Molecular Weight 159.06
  • Synonym(s) 3-Azetidinemethanamine dihydrochloride
  • SMILES NCC1CNC1.[H]Cl.[H]Cl

Description

Azetidin-3-ylmethanamine dihydrochloride delivers a reactive, bench-stable amine handle ideal for conjugation and scaffold diversification. The constrained azetidine ring imparts enhanced metabolic stability, while the protonated diamine form ensures high solubility in aqueous systems. This compound serves as a key building block in medicinal chemistry for targeted peptide coupling and macrocycle formation.

Application

Azetidin-3-ylmethanamine dihydrochloride serves as a versatile building block for the synthesis of bioactive heterocycles, particularly in medicinal chemistry. The compound functions as a key scaffold for constructing azetidine-containing pharmaceuticals due to its enhanced metabolic stability and favorable physicochemical properties. Its amine functionality enables straightforward derivatization via alkylation, acylation, or coupling reactions, while the dihydrochloride salt form ensures excellent solubility and bench stability for routine handling in synthetic workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.05
  • LogP   0.0081
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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